Category Archives: Regenerative Medicine
“Neural stem cells in the adult brain boost their levels of lipid metabolism to grow and generate new neurons. This new finding may open novel therapeutic avenues to treat age- or disease-associated loss of brain cells.”
Courtesy of Swiss Federal Institute of Technology, Zurich
A potential leap forward in the issue of post-treatment infertility.
Brain cells called pericytes can be reprogrammed into neurons with just two proteins, pointing to a novel way to treat neurodegenerative disorders.
Making new neurons in the brain may not be as hard as once believed. Using just two proteins and without any cell divisions, scientists from Ludwig-Maximilians University Munich succeeded in reprogramming brain cells known as pericytes into neurons in both cultured cells from humans and mice. The findings, published today (October 4) in Cell Stem Cell, could have implications for patients with degenerative brain disorders.
“We are not there yet, but the hope is that we can eventually treat neurodegenerative diseases like Parkinson’s by in situ reprogramming,” said Ludwig-Maximilians’ Benedikt Berninger, lead author on the study.
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More good news from an often overlooked area of stem cell research, the impact of disease modelling in accelerating the production of new drugs and treatments
van Kopen et al reported a long term therapeutic rescue function in chronic kidney disease. An MSC produced conditioned medium, administered intravenously, decreased progression of CKD and reduced hypertension and glomerular injury.
Recent work by Gepstein et al published in the European Heart Journal demonstrates the valuable potential of hiPSCs in cardiovascular regeneration.
The ability to source patient specific cells will avoid the use of allogenic grafts with their inherent rejection issues. In this case, dermal fibroblasts were reprogrammed using viral delivery of pluripotency factors and subsequently coaxed into differentiating to cardiomyocyte cells.
While this is an emerging field, this early work holds much promise and is great news for proponents of hiPSCs
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