Category Archives: Regenerative Medicine

Pathway That Stimulates Bone Growth Revealed By Veterinary Team

Pathway That Stimulates Bone Growth Revealed By Veterinary Team.


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Lipid metabolism regulates the activity of adult neural stem cells

“Neural stem cells in the adult brain boost their levels of lipid metabolism to grow and generate new neurons. This new finding may open novel therapeutic avenues to treat age- or disease-associated loss of brain cells.”

Lipid metabolism regulates the activity of adult neural stem cells.

A dormant stem cell (left, with extensions) is activated and starts cell division. The key for growth and development of the dividing cell (middle, no extensions) to the adult nerve cell (red, right), is a massive increase of fatty acid synthesis. (Image: Simon Braun, HiFo, UZH)

Courtesy of Swiss Federal Institute of Technology, Zurich


Injectable Sponges Can Expand Inside The Body To Deliver Drugs

a new delivery system with stem cell/bio scaffold opportunities. Injectable Sponges that Can Expand Inside The Body.


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Posted by on November 23, 2012 in Regenerative Medicine


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Hope for young cancer victims as stem cell transplantation restores functioning sperm in monkeys.

Link->Hope for young cancer victims as stem cell transplantation restores functioning sperm in monkeys .

A potential leap forward in the issue of post-treatment infertility.



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Brain cells called pericytes can be reprogrammed into neurons with just two proteins, pointing to a novel way to treat neurodegenerative disorders.

Making new neurons in the brain may not be as hard as once believed. Using just two proteins and without any cell divisions, scientists from Ludwig-Maximilians University Munich succeeded in reprogramming brain cells known as pericytes into neurons in both cultured cells from humans and mice. The findings, published today (October 4) in Cell Stem Cell, could have implications for patients with degenerative brain disorders.

“We are not there yet, but the hope is that we can eventually treat neurodegenerative diseases like Parkinson’s by in situ reprogramming,” said Ludwig-Maximilians’ Benedikt Berninger, lead author on the study.

Since 2011, other scientists including Marius Wernig, a stem cell biologist from the Stanford School of Medicine, have transformed skin cells directly into neurons using three or four proteins…

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Scientists grow lung cells from CF patients in lab to test drugs

More good news from an often overlooked area of stem cell research, the impact of disease modelling in accelerating the production of new drugs and treatments

Scientists grow lung cells from CF patients in lab to test drugs | CTVNews.



Carbon nanotubes and stem cell differentiation

Moon et al published a study in the International Journal of Nanomedicine providing evidence that carbon nanotubes improve stem cell differentiation in repair of damage due to stroke.
This in vivo study performed on stroke afflicted murines compared both hydophilic(HL) and hydrophobic(HP) carbon nanotubes impregnated with neural progenitor cells(NPC).

“Results showed that the HP CNT-SVZ NPC transplants improved rat behavior and reduced infarct cyst volume and infarct cyst area compared with the experimental control and the HL CNT-SVZ NPC and SVZ NPCs alone groups.”

Of Note: The findings are in favour of the positive effects of hydrophobic carbon nanotubes, both in terms of Nestin, a stemness biomarker, and proliferation around the site of injury.
“The majority of the transplanted HP CNT-SVZ NPCs collectively broadened around the ischemic injured region.”

We await further work in this area!

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MSC-derived conditioned medium (CM) attenuates chronic kidney disease in animal models

van Kopen et al reported a long term therapeutic rescue function in chronic kidney disease. An MSC produced conditioned medium, administered intravenously, decreased progression of CKD and reduced hypertension and glomerular injury.

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Newly published research into adult stem cells for cardiac regeneration

Recent work by Gepstein et al published in the European Heart Journal demonstrates the valuable potential of hiPSCs in cardiovascular regeneration.

The ability to source patient specific cells will avoid the use of allogenic grafts with their inherent rejection issues. In this case, dermal fibroblasts were reprogrammed using viral delivery of pluripotency factors and subsequently coaxed into differentiating to cardiomyocyte cells.

While this is an emerging field, this early work holds much promise and is great news for proponents of hiPSCs

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