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Category Archives: Stem Cells in Drug Discovery

Scientists Identify New Stem Cells with Therapeutic Potential

Cell Today

 The discovery, published in the journal PLOS Biology, offers new opportunities in the treatment of cardiovascular diseases, cancer and many other diseases.

The growth of new blood vessels – angiogenesis – occurs during the repair of damaged tissue and organs in adults. However, malignant tumors also grow new blood vessels in order to receive oxygen and nutrients. As such, angiogenesis is both beneficial and detrimental to health, depending on the context, requiring therapeutic approaches that can either help to stimulate or prevent it. Therapeutics that aim to prevent the growth of new blood vessels are already in use, but the results are often more modest than predicted.

For more than a decade, Prof Petri Salvén of the University of Helsinki and his colleagues have studied the mechanisms of angiogenesis to discover how blood vessel growth could be prevented or accelerated effectively.

“We succeeded in isolating endothelial cells with a high rate of division…

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Scientists grow lung cells from CF patients in lab to test drugs

More good news from an often overlooked area of stem cell research, the impact of disease modelling in accelerating the production of new drugs and treatments

Scientists grow lung cells from CF patients in lab to test drugs | CTVNews.

image: http://www.annals.org

 

iPSC models used to identify critical proteins involved in Huntingtons disease

In this study by Chae et al. published in the Biochemical Journal, 26 differentially expressed proteins were identified as being critical to the etiology of HD. In particular, superoxide dismutase 1 (SOD1) and peroxiredoxins are significantly affected, implying the significance of oxidative stress in HD.

Once again, the value of iPSC in disease modelling is demonstrated.

Link here:

http://www.biochemj.org/bj/imps/abs/BJ20111495.htm

image:Dr. Steven Finkbeiner, Gladstone Institute of Neurological Disease

 

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