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Worms teach about germline stem cells

To me, the stem cells within a germline are a perfect storm of fascination.  Stem cells are, of course, intriguing in their ability to self-renew and differentiate, and a germline is intriguing in its ability to generate gametes.  Add stem cells and germlines together, and you have amazing biology in front of you…and more biology […]

via Worms teach about germline stem cells.

 
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Posted by on October 17, 2012 in Uncategorized, World News

 

SOMEONE SOMEWHERE

Brain cells called pericytes can be reprogrammed into neurons with just two proteins, pointing to a novel way to treat neurodegenerative disorders.

Making new neurons in the brain may not be as hard as once believed. Using just two proteins and without any cell divisions, scientists from Ludwig-Maximilians University Munich succeeded in reprogramming brain cells known as pericytes into neurons in both cultured cells from humans and mice. The findings, published today (October 4) in Cell Stem Cell, could have implications for patients with degenerative brain disorders.

“We are not there yet, but the hope is that we can eventually treat neurodegenerative diseases like Parkinson’s by in situ reprogramming,” said Ludwig-Maximilians’ Benedikt Berninger, lead author on the study.

Since 2011, other scientists including Marius Wernig, a stem cell biologist from the Stanford School of Medicine, have transformed skin cells directly into neurons using three or four proteins…

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memoirs on a rainy day

The discovery that mature, adult cells can be reprogrammed back to an embryonic-like state has won this year’s Nobel Prize in Physiology or Medicine. It was awarded to two pioneers of stem-cell research, John Gurdon and Shinya Yamanaka.

Read more @ SciTechDaily

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Posted by on October 11, 2012 in Uncategorized

 

Stem cells heal heart attack scars, regrow healthy muscle

 

Scientists grow lung cells from CF patients in lab to test drugs

More good news from an often overlooked area of stem cell research, the impact of disease modelling in accelerating the production of new drugs and treatments

Scientists grow lung cells from CF patients in lab to test drugs | CTVNews.

image: http://www.annals.org

 

FDA Not Satisfied with Just 25 Percent of the U.S. Economy – Hit & Run

FDA Not Satisfied with Just 25 Percent of the U.S. Economy – Hit & Run : Reason.com.

 
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Posted by on August 8, 2012 in World News

 

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Carbon nanotubes and stem cell differentiation

Moon et al published a study in the International Journal of Nanomedicine providing evidence that carbon nanotubes improve stem cell differentiation in repair of damage due to stroke.
This in vivo study performed on stroke afflicted murines compared both hydophilic(HL) and hydrophobic(HP) carbon nanotubes impregnated with neural progenitor cells(NPC).

“Results showed that the HP CNT-SVZ NPC transplants improved rat behavior and reduced infarct cyst volume and infarct cyst area compared with the experimental control and the HL CNT-SVZ NPC and SVZ NPCs alone groups.”

Of Note: The findings are in favour of the positive effects of hydrophobic carbon nanotubes, both in terms of Nestin, a stemness biomarker, and proliferation around the site of injury.
“The majority of the transplanted HP CNT-SVZ NPCs collectively broadened around the ischemic injured region.”

We await further work in this area!

Full text here:
http://www.ncbi.nlm.nih.gov/pubmed/22701320

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MSC-derived conditioned medium (CM) attenuates chronic kidney disease in animal models

van Kopen et al reported a long term therapeutic rescue function in chronic kidney disease. An MSC produced conditioned medium, administered intravenously, decreased progression of CKD and reduced hypertension and glomerular injury.

Full text here:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0038746

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iPSC models used to identify critical proteins involved in Huntingtons disease

In this study by Chae et al. published in the Biochemical Journal, 26 differentially expressed proteins were identified as being critical to the etiology of HD. In particular, superoxide dismutase 1 (SOD1) and peroxiredoxins are significantly affected, implying the significance of oxidative stress in HD.

Once again, the value of iPSC in disease modelling is demonstrated.

Link here:

http://www.biochemj.org/bj/imps/abs/BJ20111495.htm

image:Dr. Steven Finkbeiner, Gladstone Institute of Neurological Disease

 

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Link

For anyone looking for the basics on Stem Cells, some useful links

http://www.isscr.org/public/ISSCR08_PubEdBroch.pdf

http://www.eurostemcell.org/faq/14

 

 
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Posted by on June 16, 2012 in Stem Cells 101

 

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