A potential leap forward in the issue of post-treatment infertility.
The growth of new blood vessels – angiogenesis – occurs during the repair of damaged tissue and organs in adults. However, malignant tumors also grow new blood vessels in order to receive oxygen and nutrients. As such, angiogenesis is both beneficial and detrimental to health, depending on the context, requiring therapeutic approaches that can either help to stimulate or prevent it. Therapeutics that aim to prevent the growth of new blood vessels are already in use, but the results are often more modest than predicted.
For more than a decade, Prof Petri Salvén of the University of Helsinki and his colleagues have studied the mechanisms of angiogenesis to discover how blood vessel growth could be prevented or accelerated effectively.
“We succeeded in isolating endothelial cells with a high rate of division…
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Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency | Stu’s Stem Cell Blog
The mechanisms of reprogramming are being slowly uncovered. Here’s an excellent post from Stu’s Stem Cell Blog:
To me, the stem cells within a germline are a perfect storm of fascination. Stem cells are, of course, intriguing in their ability to self-renew and differentiate, and a germline is intriguing in its ability to generate gametes. Add stem cells and germlines together, and you have amazing biology in front of you…and more biology […]
Brain cells called pericytes can be reprogrammed into neurons with just two proteins, pointing to a novel way to treat neurodegenerative disorders.
Making new neurons in the brain may not be as hard as once believed. Using just two proteins and without any cell divisions, scientists from Ludwig-Maximilians University Munich succeeded in reprogramming brain cells known as pericytes into neurons in both cultured cells from humans and mice. The findings, published today (October 4) in Cell Stem Cell, could have implications for patients with degenerative brain disorders.
“We are not there yet, but the hope is that we can eventually treat neurodegenerative diseases like Parkinson’s by in situ reprogramming,” said Ludwig-Maximilians’ Benedikt Berninger, lead author on the study.
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The discovery that mature, adult cells can be reprogrammed back to an embryonic-like state has won this year’s Nobel Prize in Physiology or Medicine. It was awarded to two pioneers of stem-cell research, John Gurdon and Shinya Yamanaka.
Read more @ SciTechDaily