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iPSC models used to identify critical proteins involved in Huntingtons disease

In this study by Chae et al. published in the Biochemical Journal, 26 differentially expressed proteins were identified as being critical to the etiology of HD. In particular, superoxide dismutase 1 (SOD1) and peroxiredoxins are significantly affected, implying the significance of oxidative stress in HD.

Once again, the value of iPSC in disease modelling is demonstrated.

Link here:

http://www.biochemj.org/bj/imps/abs/BJ20111495.htm

image:Dr. Steven Finkbeiner, Gladstone Institute of Neurological Disease

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