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Nice article on Wnt signalling

Intestinal homeostasis and stem cells are not affected when Paneth cells stop producing Wnt, but Wnt is required to maintain the stem cell niche in intestinal epithelial cultures, according to a mouse study in the December issue of Gastroenterology. These findings indicate that underlying mesenchymal cells provide a secondary physiological source of Wnt to intestinal stem cells.

Wnt signaling regulates many aspects of intestinal physiology, and also maintains stem cells. Paneth cells (which reside at the base of the crypt, interspersed with Lgr5+ stem cells) support the stem cells, producing important signaling factors. These include the Wnt ligands Wnt3, Wnt6, and Wnt9b; the Notch ligands Dll-1 and Dll-4; and EGF. However, it is not clear if Paneth cell production of all these factors is required to maintain the stem cell niche.

To examine the roles of Wnt production in the intestinal epithelia, Henner Farin et al. created mice…

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Posted by on December 4, 2012 in Uncategorized

 

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Injectable Sponges Can Expand Inside The Body To Deliver Drugs

a new delivery system with stem cell/bio scaffold opportunities. Injectable Sponges that Can Expand Inside The Body.

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Posted by on November 23, 2012 in Regenerative Medicine

 

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Hope for young cancer victims as stem cell transplantation restores functioning sperm in monkeys.

Link->Hope for young cancer victims as stem cell transplantation restores functioning sperm in monkeys .

A potential leap forward in the issue of post-treatment infertility.

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iPSC models used to identify critical proteins involved in Huntingtons disease

In this study by Chae et al. published in the Biochemical Journal, 26 differentially expressed proteins were identified as being critical to the etiology of HD. In particular, superoxide dismutase 1 (SOD1) and peroxiredoxins are significantly affected, implying the significance of oxidative stress in HD.

Once again, the value of iPSC in disease modelling is demonstrated.

Link here:

http://www.biochemj.org/bj/imps/abs/BJ20111495.htm

image:Dr. Steven Finkbeiner, Gladstone Institute of Neurological Disease

 

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New hypothesis on vascular remodelling & diseases

Challenging existing theories on vascular remodelling and diseases, a paper by Tang et al describes how multipotent vascular stem cells contribute to vascular remodelling by differentiating into smooth muscle cells and chondrogenic cells.

Source here:
http://www.nature.com/ncomms/journal/v3/n6/full/ncomms1867.html

Image: Song Li

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